| 1 | Youth in Revolt (The Weinstein Company) | $15,275,517 | $6,888,334 | $2,296,111 | Jan 08, 2010 |
| 2 | You Again (Disney) | $25,702,053 | $8,407,513 | $2,802,504 | Sep 24, 2010 |
| 3 | Yogi Bear (Warner Bros.) | $100,246,011 | $16,411,322 | $5,470,441 | Dec 17, 2010 |
| 4 | Winter's Bone (Roadside Attractions) | $6,531,503 | $84,887 | $28,296 | Jun 11, 2010 |
| 5 | When in Rome (Disney) | $32,669,055 | $12,350,041 | $4,116,680 | Jan 29, 2010 |
| 6 | Wall Street: Money Never Sleeps (Fox) | $52,474,616 | $19,011,188 | $6,337,063 | Sep 24, 2010 |
| 7 | Waiting for 'Superman' (Paramount Vantage) | $6,417,135 | $139,033 | $46,344 | Sep 24, 2010 |
| 8 | Vampires Suck (Fox) | $36,661,504 | $12,202,831 | $4,067,610 | Aug 18, 2010 |
| 9 | Valentine's Day (Warner Bros. / New Line) | $110,486,000 | $56,260,707 | $18,753,569 | Feb 12, 2010 |
| 10 | Unstoppable (2010) (Fox) | $81,562,942 | $22,688,457 | $7,562,819 | Nov 12, 2010 |
| 11 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | $60,095,852 | $29,289,537 | $9,763,179 | Apr 02, 2010 |
| 12 | True Grit (2010) (Paramount) | $171,050,328 | $24,830,443 | $8,276,814 | Dec 22, 2010 |
| 13 | TRON: Legacy (Disney) | $172,062,763 | $44,026,211 | $14,675,404 | Dec 17, 2010 |
| 14 | Toy Story 3 (Disney) | $415,004,880 | $110,307,189 | $36,769,063 | Jun 18, 2010 |
| 15 | The Wolfman (Universal) | $61,979,680 | $31,479,235 | $10,493,078 | Feb 12, 2010 |
| 16 | The Warrior's Way (Relativity Media) | $5,657,614 | $3,048,665 | $1,016,222 | Dec 03, 2010 |
| 17 | The Twilight Saga: Eclipse (Summit) | $300,531,751 | $64,832,191 | $21,610,730 | Jun 30, 2010 |
| 18 | The Town (Warner Bros.) | $92,186,262 | $23,808,032 | $7,936,011 | Sep 17, 2010 |
| 19 | The Tourist (Sony / Columbia) | $67,631,157 | $16,472,458 | $5,490,819 | Dec 10, 2010 |
| 20 | The Tooth Fairy (Fox) | $60,022,256 | $14,010,409 | $4,670,136 | Jan 22, 2010 |
| 21 | The Switch (2010) (Miramax) | $27,779,426 | $8,436,713 | $2,812,238 | Aug 20, 2010 |
| 22 | The Spy Next Door (Lionsgate) | $24,307,832 | $9,726,056 | $3,242,019 | Jan 15, 2010 |
| 23 | The Sorcerer's Apprentice (Disney) | $63,150,991 | $17,619,622 | $5,873,207 | Jul 14, 2010 |
| 24 | The Social Network (Sony / Columbia) | $96,962,694 | $22,445,653 | $7,481,884 | Oct 01, 2010 |
| 25 | The Secret in Their Eyes (2010) (Sony Pictures Classics) | $6,391,436 | $167,866 | $55,955 | Apr 16, 2010 |
| 26 | The Other Guys (Sony / Columbia) | $119,219,978 | $35,543,162 | $11,847,721 | Aug 06, 2010 |
| 27 | The Next Three Days (Lionsgate) | $21,148,651 | $6,542,779 | $2,180,926 | Nov 19, 2010 |
| 28 | The Losers (Warner Bros.) | $23,591,432 | $9,406,348 | $3,135,449 | Apr 23, 2010 |
| 29 | The Last Station (Sony Pictures Classics) | $6,617,867 | $73,723 | $24,574 | Jan 15, 2010 |
| 30 | The Last Song (Disney) | $62,950,384 | $16,007,426 | $5,335,809 | Mar 31, 2010 |
| 31 | The Last Exorcism (Lionsgate) | $41,034,350 | $20,366,613 | $6,788,871 | Aug 27, 2010 |
| 32 | The Last Airbender (Paramount) | $131,601,062 | $40,325,019 | $13,441,673 | Jul 01, 2010 |
| 33 | The King's Speech (Weinstein Company) | $138,797,449 | $355,450 | $118,483 | Nov 26, 2010 |
| 34 | The Kids Are All Right (Focus) | $20,811,365 | $491,971 | $163,990 | Jul 09, 2010 |
| 35 | The Karate Kid (2010) (Sony / Columbia) | $176,591,618 | $55,665,805 | $18,555,268 | Jun 11, 2010 |
| 36 | The Girl with the Dragon Tattoo (2009) (Music Box) | $10,095,170 | $335,502 | $111,834 | Mar 19, 2010 |
| 37 | The Girl Who Played With Fire (Music Box) | $7,638,241 | $904,998 | $301,666 | Jul 09, 2010 |
| 38 | The Girl Who Kicked the Hornet's Nest (Music Box) | $5,189,452 | $723,301 | $241,100 | Oct 29, 2010 |
| 39 | The Ghost Writer (Summit) | $15,541,549 | $183,009 | $61,003 | Feb 19, 2010 |
| 40 | The Fighter (Paramount) | $93,617,009 | $300,010 | $100,003 | Dec 10, 2010 |
| 41 | The Expendables (Lionsgate) | $103,068,524 | $34,825,135 | $11,608,378 | Aug 13, 2010 |
| 42 | The Crazies (Overture) | $39,123,589 | $16,067,552 | $5,355,851 | Feb 26, 2010 |
| 43 | The Chronicles of Narnia: The Voyage of the Dawn Treader (Fox) | $104,386,950 | $24,005,069 | $8,001,690 | Dec 10, 2010 |
| 44 | The Bounty Hunter (Sony / Columbia) | $67,061,228 | $20,686,423 | $6,895,474 | Mar 19, 2010 |
| 45 | The Book of Eli (Warner Bros.) | $94,835,000 | $32,789,494 | $10,929,831 | Jan 15, 2010 |
| 46 | The Back-up Plan (CBS Films) | $37,490,007 | $12,201,710 | $4,067,237 | Apr 23, 2010 |
| 47 | The A-Team (Fox) | $77,222,099 | $25,669,455 | $8,556,485 | Jun 11, 2010 |
| 48 | The American (Focus) | $35,606,376 | $13,177,790 | $4,392,597 | Sep 01, 2010 |
| 49 | Tangled (Disney) | $200,821,936 | $48,767,052 | $16,255,684 | Nov 24, 2010 |
| 50 | Takers (Sony / Screen Gems) | $57,744,720 | $20,512,304 | $6,837,435 | Aug 27, 2010 |
| 51 | Step Up 3D (Disney) | $42,400,223 | $15,812,311 | $5,270,770 | Aug 06, 2010 |
| 52 | Splice (Warner Bros) | $17,010,170 | $7,385,000 | $2,461,667 | Jun 04, 2010 |
| 53 | Skyline (Universal / Rogue) | $21,393,620 | $11,692,415 | $3,897,472 | Nov 12, 2010 |
| 54 | Shutter Island (Paramount) | $128,012,934 | $41,062,440 | $13,687,480 | Feb 19, 2010 |
| 55 | Shrek Forever After (Paramount / DreamWorks) | $238,395,990 | $70,838,207 | $23,612,736 | May 21, 2010 |
| 56 | She's Out of My League (Paramount) | $31,628,317 | $9,775,278 | $3,258,426 | Mar 12, 2010 |
| 57 | Sex and the City 2 (Warner Bros. / New Line) | $95,347,692 | $31,002,000 | $10,334,000 | May 27, 2010 |
| 58 | Secretariat (Disney) | $59,713,955 | $12,694,770 | $4,231,590 | Oct 08, 2010 |
| 59 | Scott Pilgrim vs. the World (Universal) | $31,524,275 | $10,609,795 | $3,536,598 | Aug 13, 2010 |
| 60 | Saw 3D (Lionsgate) | $45,710,178 | $24,230,123 | $8,076,708 | Oct 29, 2010 |
| 61 | Salt (Sony / Columbia) | $118,311,368 | $36,011,243 | $12,003,748 | Jul 23, 2010 |
| 62 | Robin Hood (2010) (Universal) | $105,269,730 | $36,063,000 | $12,021,000 | May 14, 2010 |
| 63 | Resident Evil: Afterlife (Sony / Screen Gems) | $60,128,566 | $26,650,264 | $8,883,421 | Sep 10, 2010 |
| 64 | Repo Men (Universal) | $13,794,389 | $6,126,170 | $2,042,057 | Mar 19, 2010 |
| 65 | Remember Me (Summit) | $19,068,240 | $8,089,139 | $2,696,380 | Mar 12, 2010 |
| 66 | Red (2010) (Summit) | $90,380,162 | $21,761,408 | $7,253,803 | Oct 15, 2010 |
| 67 | Ramona and Beezus (Fox) | $26,167,002 | $7,810,481 | $2,603,494 | Jul 23, 2010 |
| 68 | Prince of Persia: The Sands of Time (Disney) | $90,759,676 | $30,095,259 | $10,031,753 | May 28, 2010 |
| 69 | Predators (Fox) | $52,000,688 | $24,760,882 | $8,253,627 | Jul 09, 2010 |
| 70 | Piranha 3D (Weinstein Company) | $25,003,155 | $10,106,872 | $3,368,957 | Aug 20, 2010 |
| 71 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | $88,761,720 | $31,236,067 | $10,412,022 | Feb 12, 2010 |
| 72 | Paranormal Activity 2 (Paramount) | $84,752,907 | $40,678,424 | $13,559,475 | Oct 22, 2010 |
| 73 | Our Family Wedding (Fox Searchlight) | $20,250,000 | $7,629,862 | $2,543,287 | Mar 12, 2010 |
| 74 | Oceans (Disneynature) | $19,422,319 | $6,058,958 | $2,019,653 | Apr 22, 2010 |
| 75 | Nanny McPhee Returns (Universal) | $29,011,215 | $8,407,685 | $2,802,562 | Aug 20, 2010 |
| 76 | My Soul to Take (Universal / Rogue) | $14,744,435 | $6,842,220 | $2,280,740 | Oct 08, 2010 |
| 77 | Morning Glory (2010) (Paramount) | $31,011,732 | $9,203,266 | $3,067,755 | Nov 10, 2010 |
| 78 | Megamind (Paramount / DreamWorks) | $148,415,853 | $46,016,833 | $15,338,944 | Nov 05, 2010 |
| 79 | Marmaduke (Fox) | $33,644,788 | $11,599,661 | $3,866,554 | Jun 04, 2010 |
| 80 | Machete (Fox) | $26,593,646 | $11,416,164 | $3,805,388 | Sep 03, 2010 |
| 81 | MacGruber (Universal / Rogue) | $8,525,600 | $4,043,000 | $1,347,667 | May 21, 2010 |
| 82 | Love and Other Drugs (Fox) | $32,367,005 | $9,739,161 | $3,246,387 | Nov 24, 2010 |
| 83 | Lottery Ticket (Warner Bros.) | $24,719,879 | $10,652,297 | $3,550,766 | Aug 20, 2010 |
| 84 | Little Fockers (Universal) | $148,438,600 | $30,833,665 | $10,277,888 | Dec 22, 2010 |
| 85 | Life As We Know It (Warner Bros.) | $53,374,681 | $14,506,464 | $4,835,488 | Oct 08, 2010 |
| 86 | Letters to Juliet (Summit) | $53,032,453 | $13,540,486 | $4,513,495 | May 14, 2010 |
| 87 | Let Me In (Relativity / Overture) | $12,134,935 | $5,147,479 | $1,715,826 | Oct 01, 2010 |
| 88 | Legion (Sony / Screen Gems) | $40,168,080 | $17,501,625 | $5,833,875 | Jan 22, 2010 |
| 89 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | $55,675,313 | $16,112,211 | $5,370,737 | Sep 24, 2010 |
| 90 | Leap Year (2010) (Universal) | $25,918,802 | $9,202,815 | $3,067,605 | Jan 08, 2010 |
| 91 | Knight and Day (Fox) | $76,423,035 | $20,139,985 | $6,713,328 | Jun 23, 2010 |
| 92 | Killers (2010) (Lionsgate) | $47,059,963 | $15,837,266 | $5,279,089 | Jun 04, 2010 |
| 93 | Kick-Ass (Lionsgate) | $48,071,303 | $19,828,687 | $6,609,562 | Apr 16, 2010 |
| 94 | Just Wright (Fox Searchlight) | $21,524,012 | $8,284,989 | $2,761,663 | May 14, 2010 |
| 95 | Jonah Hex (Warner Bros.) | $10,547,117 | $5,379,000 | $1,793,000 | Jun 18, 2010 |
| 96 | Jackass 3D (Paramount) | $117,229,692 | $50,353,641 | $16,784,547 | Oct 15, 2010 |
| 97 | It's Kind of a Funny Story (Focus) | $6,363,628 | $2,013,406 | $671,135 | Oct 08, 2010 |
| 98 | Iron Man 2 (Paramount) | $312,128,345 | $128,122,480 | $42,707,493 | May 07, 2010 |
| 99 | Inception (Warner Bros.) | $292,576,195 | $62,785,337 | $20,928,446 | Jul 16, 2010 |
| 100 | I Am Love (Magnolia) | $5,005,465 | $121,504 | $40,501 | Jun 18, 2010 |
| 101 | Hubble 3D (Warner Bros. / IMAX) | $52,522,904 | $410,920 | $136,973 | Mar 19, 2010 |
| 102 | How to Train Your Dragon (Paramount / DreamWorks) | $217,581,231 | $43,732,319 | $14,577,440 | Mar 26, 2010 |
| 103 | How Do You Know (Sony / Columbia) | $30,212,620 | $7,484,696 | $2,494,899 | Dec 17, 2010 |
| 104 | Hot Tub Time Machine (MGM) | $50,288,000 | $14,020,502 | $4,673,501 | Mar 26, 2010 |
| 105 | Hereafter (Warner Bros.) | $32,746,941 | $220,322 | $73,441 | Oct 15, 2010 |
| 106 | Harry Potter and the Deathly Hallows: Part 1 (Warner Bros.) | $295,983,305 | $125,017,372 | $41,672,457 | Nov 19, 2010 |
| 107 | Gulliver's Travels (2010) (Fox) | $42,779,261 | $6,307,691 | $2,102,564 | Dec 25, 2010 |
| 108 | Grown Ups (Sony / Columbia) | $162,001,186 | $40,506,562 | $13,502,187 | Jun 25, 2010 |
| 109 | Green Zone (Universal) | $35,053,660 | $14,309,295 | $4,769,765 | Mar 12, 2010 |
| 110 | Going the Distance (2010) (Warner Bros. / New Line) | $17,804,299 | $6,884,964 | $2,294,988 | Sep 03, 2010 |
| 111 | Get Low (Sony Pictures Classics) | $9,176,933 | $88,182 | $29,394 | Jul 30, 2010 |
| 112 | Get Him to the Greek (Universal) | $60,974,475 | $17,571,000 | $5,857,000 | Jun 04, 2010 |
| 113 | Furry Vengeance (Summit) | $17,630,465 | $6,627,564 | $2,209,188 | Apr 30, 2010 |
| 114 | From Paris with Love (Lionsgate) | $24,077,225 | $8,158,860 | $2,719,620 | Feb 05, 2010 |
| 115 | For Colored Girls (Lionsgate) | $37,729,698 | $19,497,324 | $6,499,108 | Nov 05, 2010 |
| 116 | Faster (2010) (CBS Films) | $23,240,020 | $8,523,153 | $2,841,051 | Nov 24, 2010 |
| 117 | Fair Game (2010) (Summit) | $9,540,691 | $651,082 | $217,027 | Nov 05, 2010 |
| 118 | Extraordinary Measures (CBS Films) | $12,482,946 | $6,012,594 | $2,004,198 | Jan 22, 2010 |
| 119 | Edge of Darkness (Warner Bros.) | $43,313,294 | $17,214,384 | $5,738,128 | Jan 29, 2010 |
| 120 | Eat Pray Love (Sony / Columbia) | $80,574,010 | $23,104,523 | $7,701,508 | Aug 13, 2010 |
| 121 | Easy A (Sony / Screen Gems) | $58,401,464 | $17,734,040 | $5,911,347 | Sep 17, 2010 |
| 122 | Due Date (Warner Bros.) | $100,539,043 | $32,689,406 | $10,896,469 | Nov 05, 2010 |
| 123 | Dinner for Schmucks (Paramount / DreamWorks) | $73,026,337 | $23,527,839 | $7,842,613 | Jul 30, 2010 |
| 124 | Diary of a Wimpy Kid (Fox) | $64,003,625 | $22,126,166 | $7,375,389 | Mar 19, 2010 |
| 125 | Devil (Universal) | $33,601,190 | $12,289,375 | $4,096,458 | Sep 17, 2010 |
| 126 | Despicable Me (Universal) | $251,513,985 | $56,397,125 | $18,799,042 | Jul 09, 2010 |
| 127 | Death at a Funeral (2010) (Sony / Screen Gems) | $42,739,347 | $16,217,540 | $5,405,847 | Apr 16, 2010 |
| 128 | Dear John (Sony / Screen Gems) | $80,014,842 | $30,468,614 | $10,156,205 | Feb 05, 2010 |
| 129 | Daybreakers (Lionsgate) | $30,101,144 | $15,146,692 | $5,048,897 | Jan 08, 2010 |
| 130 | Date Night (Fox) | $98,711,404 | $25,207,599 | $8,402,533 | Apr 09, 2010 |
| 131 | Cyrus (Fox Searchlight) | $7,455,447 | $181,716 | $60,572 | Jun 18, 2010 |
| 132 | Country Strong (Sony / Screen Gems) | $20,218,921 | $30,452 | $10,151 | Dec 22, 2010 |
| 133 | Cop Out (Warner Bros.) | $44,875,000 | $18,211,126 | $6,070,375 | Feb 26, 2010 |
| 134 | Conviction (Fox Searchlight) | $6,783,129 | $102,351 | $34,117 | Oct 15, 2010 |
| 135 | Clash of the Titans (2010) (Warner Bros.) | $163,214,888 | $61,235,105 | $20,411,702 | Apr 02, 2010 |
| 136 | City Island (Anchor Bay) | $6,671,036 | $32,001 | $10,667 | Mar 19, 2010 |
| 137 | Charlie St. Cloud (Universal) | $31,162,545 | $12,381,585 | $4,127,195 | Jul 30, 2010 |
| 138 | Cats & Dogs: The Revenge of Kitty Galore (Warner Bros.) | $43,585,753 | $12,279,363 | $4,093,121 | Jul 30, 2010 |
| 139 | Case 39 (Paramount Vantage) | $13,261,851 | $5,350,570 | $1,783,523 | Oct 01, 2010 |
| 140 | Burlesque (Sony / Screen Gems) | $39,440,655 | $11,947,744 | $3,982,581 | Nov 24, 2010 |
| 141 | Brooklyn's Finest (Overture) | $27,163,593 | $13,350,299 | $4,450,100 | Mar 05, 2010 |
| 142 | Blue Valentine (2010) (Weinstein Company) | $9,706,328 | $193,728 | $64,576 | Dec 29, 2010 |
| 143 | Black Swan (Fox Searchlight) | $106,954,678 | $1,443,809 | $481,270 | Dec 03, 2010 |
| 144 | Biutiful (Roadside Attractions) | $5,101,237 | $45,293 | $15,098 | Dec 29, 2010 |
| 145 | Babies (Focus) | $7,320,323 | $2,161,460 | $720,487 | May 07, 2010 |
| 146 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | $63,075,011 | $32,902,000 | $10,967,333 | Apr 30, 2010 |
| 147 | Alpha and Omega (Lionsgate) | $25,107,267 | $9,106,906 | $3,035,635 | Sep 17, 2010 |
| 148 | Alice in Wonderland (2010) (Disney) | $334,191,110 | $116,101,023 | $38,700,341 | Mar 05, 2010 |
| 149 | 127 Hours (Fox Searchlight) | $18,335,230 | $264,851 | $88,284 | Nov 05, 2010 |
